Hypoosmotic Cell Swelling as a Novel Mechanism for Modulation of Cloned HCN2 Channels
نویسندگان
چکیده
منابع مشابه
Hypoosmotic Sperm Swelling Test: Reevaluation of Its Potential Use
The aim of this study was to assess the predictive value of the hypoosmotic sperm swelling test. Good correlations were observed between the percentage of spermatozoa undergoing swelling and the percentage motility both in normal (r = 0.68; p < 0.001) and infertile patients (r = 0.65; p < 0.001). In contrast, sperm swelling did not significandy correlate either with sperm oocyte fusion (assesse...
متن کاملActivation gating in HCN2 channels
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels control electrical rhythmicity in specialized brain and heart cells. We quantitatively analysed voltage-dependent activation of homotetrameric HCN2 channels and its modulation by the second messenger cAMP using global fits of hidden Markovian models to complex experimental data. We show that voltage-dependent activation is e...
متن کاملElementary functional properties of single HCN2 channels.
Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels are tetramers that evoke rhythmic electrical activity in specialized neurons and cardiac cells. These channels are activated by hyperpolarizing voltage, and the second messenger cAMP can further enhance the activation. Despite the physiological importance of HCN channels, their elementary functional properties are still unclear....
متن کاملHypoosmotic swelling test in young Nelore bulls classified as sound and unsound for breeding
This work aimed to study the correlations between the physical characteristics of semen, sperm morphology and the biochemical integrity of the plasmatic membrane of raw sperm in young Nelore bulls (Bos taurus indicus). A total of 420 bulls between 18 and 22 months of age were examined for breeding soundness according to the criteria established by the Brazilian College of Animal Reproduction. A...
متن کاملPositive allosteric modulation of TRPV1 as a novel analgesic mechanism
BACKGROUND The prevalence of long-term opiate use in treating chronic non-cancer pain is increasing, and prescription opioid abuse and dependence are a major public health concern. To explore alternatives to opioid-based analgesia, the present study investigates a novel allosteric pharmacological approach operating through the cation channel TRPV1. This channel is highly expressed in subpopulat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2005
ISSN: 0006-3495
DOI: 10.1529/biophysj.105.063792